&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
We love digestive research. We enjoy working in teams. We embrace diversity. Together we will achieve more.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center

Highlighted Publications

The gut, its microbiome, and the brain: connections and communications
2021
Authors: Michael D Gershon, Kara Gross Margolis
Journal: J Clin Invest
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
2021
Authors: Utpal Pajvani Lab
Journal: Nat Commun
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York
2021
Authors: Catrin Uhlemann Lab
Journal: Nature
Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome
2021
Authors: Fay Kastrinos and Chir Hur Labs
Journal: Gastroenterology
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
2021
Authors: Utpal Pajvani and Ira Tabas Labs
Journal: Sci Transl Med
Maladaptive regeneration – the reawakening of developmental pathways in NASH and fibrosis
2021
Authors: Utpal Pajvani, Ira Tabas, and Robert Schwabe Groups
Journal: Nat Rev Gastroenterol Hepatol
Mutant p53 regulates Survivin to foster lung metastasis
2021
Authors: Anil Rustgi, Jianhuan Hu, and dHiroshi Nakagawa Labs
Journal: Genes Dev
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice
2021
Authors: Timothy Wang and Helen Remotti Labs
Journal: Gastroenterology
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
2021
Authors: Robert Schwabe, Nicholas Arpaia, Helen Remotti, and Peter Sims Labs
Journal: Cancer Cell
Robust direct digital-to-biological data storage in living cells
2021
Authors: Harris Wang Lab
Journal: Nat Chem Biol
Stem cells and origins of cancer in the upper gastrointestinal tract
2021
Authors: Hiroshi Nakagawa, Anil Rustgi, Jianwen Que, and Timothy Wang
Journal: Cell Stem Cell
Systematic dissection of σ70 sequence diversity and function in bacteria
2021
Authors: Harris Wang Lab
Journal: Cell Rep
The Microbiota-Gut-Brain Axis: From Motility to Mood
2021
Authors: Kara Margolis
Journal: Gastroenterology
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts
2021
Authors: Robert Schwabe, Nicholas Arpaia, Peter Sims, and Ken Olive Labs
Journal: J Clin Invest
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
2020
Authors: Ira Tabas, Utpal Pajvani, and Robert Schwabe Groups
Journal: Cell Metabol
Cysteine depletion induces pancreatic tumor ferroptosis in mice
2020
Authors: Kenneth Olive's Group
Journal: Science
Efferocytosis in health and disease
2020
Authors: Ira Tabas
Journal: Nat Rev Immunol
Gastrointestinal Symptoms and Coronavirus Disease 2019: A Case-Control Study From the United States
2020
Authors: Daniel Freedberg, Benjamin Lebwohl, and Timothy Wang Groups
Journal: Gastroenterology
Gut microbiome in HCC – Mechanisms, diagnosis and therapy
2020
Authors: Robert Schwabe
Journal: J Hepatol
Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response
2020
Authors: Ken Olive, Yang Han, and Helen Remotti Groups
Journal: Clin Cancer Res
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
2020
Authors: Ira Tabas, Bill Blaner, and Robert Schwabe Groups
Journal: Cell Metabol
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
2020
Authors: Robert Schwabe, Ira Tabas, and Utpal Pajvani Groups
Journal: Gastroenterology
Mechanobiology of vertebrate gut morphogenesis
2020
Authors: Nandan Nerurkar
Journal: Curr Opin Genet Dev
Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
2020
Authors: Timothy Wang and Kelley Yan Groups
Journal: Nat Commun
Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform
2020
Authors: Harris Wang and Daniel Freedberg Groups
Journal: Nat Commun
SnapShot: Ferroptosis
2020
Authors: Brent Stockwell
Journal: Cell