The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.

Columbia University
Digestive and Liver Diseases Research Center
 
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
 
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
 
 
We love digestive research. We enjoy working in teams. We embrace diversity. Together we will achieve more.
Columbia University
Digestive and Liver Diseases Research Center
 
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
 
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center

Highlighted Publications

“Regulation and function of insulin and insulin-like growth factor receptor signalling.”
2025-07-22 15:38:27
Authors: Eunhee Choi
Journal: Nature Reviews in Molecular and Cellular Biology
“Material properties of the embryonic small intestine during buckling morphogenesis.”
2025-07-22 15:36:15
Authors: Nandan L. Nerurkar
Journal: Acta Biomaterialia
“Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.”
2025-07-22 15:33:35
Authors: Helen Remotti, Rebecca Haeusler, Utpal Pajvani, Nicholas Arpaia, Brent Stockwell, Robert Schwabe
Journal: Nature
“p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus.”
2025-07-22 15:29:19
Authors: Jianwen Que, Timothy Wang
Journal: Gut
“Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis.”
2025-07-22 15:26:28
Authors: Timothy Wang
Journal: Nature
“Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.”
2025-07-22 15:23:13
Authors: Ira Tabas
Journal: Hepatology
“RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition.”
2025-07-22 15:21:17
Authors: Jianwen Que
Journal: Nature
“Gut colonization with vancomycin-resistant Enterococcus shapes the gut microbiome in the intensive care unit.”
2025-07-22 15:18:31
Authors: Julian Abrams, Anne-Catrin Uhlemann and Daniel Freedberg
Journal: Journal of Infectious Diseases
“AGA Living Clinical Practice Guideline on Computer-Aided Detection-Assisted Colonoscopy.”
2025-07-22 15:15:09
Authors: Benjamin Lebwohl
Journal: Gastroenterology
“Scalable co-sequencing of RNA and DNA from individual nuclei.”
2025-07-22 15:11:00
Authors: Peter Sims
Journal: Nature Methods
“SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome.”
2025-07-21 14:02:43
Authors: Harris Wang
Journal: Nature Microbiology
“Impact of population screening for Lynch syndrome insights from the All of Us data.”
2025-01-23 21:30:17
Authors: Chin Hur, Fay Kastrinos
Journal: Nature
“p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus.”
2025-01-23 21:25:46
Authors: Jianwen Que, Timothy Wang
Journal: Gut
“Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.”
2024-01-23 21:23:25
Authors: Ira Tabas
Journal: Hepatology
“Protective hepatocyte signals restrain liver fibrosis in metabolic dysfunction-associated steatohepatitis.”
2024-01-23 21:20:49
Authors: Utpal Pajvani, Robert Schwabe
Journal: Journal of Clinical Investigation
“Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.”
2024-01-23 21:17:54
Authors: Kenneth Olive
Journal: Nature
“Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids.”
2024-01-23 21:15:03
Authors: Julian Abrams, Hiroshi Nakagawa
Journal: Biomolecules
“Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State.”
2024-01-23 21:10:53
Authors: Julian Abrams, Hiroshi Nakagawa, Joel Gabre
Journal: Biomolecules
“Shifts in Serum Bile Acid Profiles Associated With Barrett’s Esophagus and Stages of Progression to Esophageal Adenocarcinoma.”
2024-01-23 21:07:05
Authors: Anil Rustgi, Timothy Wang, Harris Wang, Julian Abrams
Journal: Clinical and Translational Gastroenterology
“Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells.”
2024-01-23 21:04:21
Authors: Arnold Han, Timothy Wang, Peter Sims, Kelley Yan
Journal: Cell
“Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury.”
2024-01-23 20:56:32
Authors: Chia-Wei Cheng, Kelley Yan, Timothy Wang
Journal: Cell
“Context-dependent role of group 3 innate lymphoid cells in mucosal protection.”
2024-01-23 20:50:35
Authors: Harris Wang, Ivaylo Ivanov
Journal: Science Immunology
“Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration.”
2023-12-05 22:59:57
Authors: Kelley Yan, Timothy Wang
Journal: Cellular and Molecular Gastroenterology and Hepatology
“High-throughput microbial culturomics using automation and machine learning.”
2023-12-05 22:58:02
Authors: Harris Wang
Journal: Nature Biotechnology
“More than a few good women: honoring the ladies of the liver.”
2023-12-05 22:55:58
Authors: Elizabeth Verna
Journal: Liver Transplantation
“Confronting Disparities in Telehepatology Research.”
2023-12-05 22:53:58
Authors: Elizabeth Verna
Journal: Clinical Gastroenterology and Hepatology
“Circulating indian hedgehog is a marker of the hepatocyte-TAZ pathway in experimental NASH and is elevated in humans with NASH.”
2023-12-05 22:51:22
Authors: Ira Tabas
Journal: Journal of Hepatology- Reports
“Human embryoids: A new strategy of recreating the first steps of embryonic development in vitro.”
2023-12-05 22:47:54
Authors: Mijo Simunovic
Journal: Seminars in Cell and Developmental Biology
“A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.”
2023-12-05 22:44:00
Authors: Ira Tabas, Helen Remotti, Robert Schwabe
Journal: Gastroenterology
“Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets.”
2023-12-05 22:41:35
Authors: Ricardo Cruz-Acuna, Anil Rustgi
Journal: Journal of Clinical Investigation
“SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division.”
2023-12-05 22:37:54
Authors: Julian Abrams, Hiroshi Nakagawa, Anil Rustgi, Timothy Wang, Jianwen Que
Journal: Gastroenterology
“Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis.”
2023-12-05 22:33:35
Authors: Utpal Pajvani
Journal: Journal of Clinical Investigation Insights
“A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.”
2023-12-05 22:30:41
Authors: Nandan Nerurkar
Journal: Development
“A Call to Action: Furthering the Utilization of Technical Variants Pediatric Liver Transplantation Through Increased Awareness and Education.”
2023-12-05 22:27:17
Authors: Mercedes Martinez
Journal: Transplantation
“Correlations Between Relative Prevalence of Celiac Disease and Sociodemographic Variables in the United States.”
2023-12-05 22:24:12
Authors: Benjamin Lebwohl
Journal: American Journal of Gastroenterology
“Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10.”
2023-12-05 22:19:12
Authors: Ivaylo Ivanov
Journal: Immunity
“Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease.”
2023-12-05 22:16:25
Authors: Benjamin Lebwohl, Kelley Yan, Arnold Han
Journal: Science Immunology
“The 16α-hydroxylated Bile Acid, Pythocholic Acid Decreases Food Intake and Increases Oleoylethanolamide in Male Mice.”
2023-12-05 22:13:55
Authors: Rebecca Haeusler
Journal: Endocrinology
“Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not.”
2023-12-05 22:11:30
Authors: Daniel Freedberg
Journal: Inflammatory Bowel Disease
“How to control hunger.”
2023-12-05 22:08:21
Authors: Eunhee Choi
Journal: Nature Structural and Molecular Biology
“Modeling Notch Activity and Lineage Decisions Using Intestinal Organoids.”
2023-12-05 22:04:56
Authors: Chia-Wei Cheng
Journal: Methods in Molecular Biology
“Dietary Vitamin A Affects the Function of Incretin-Producing Enteroendocrine Cells in Male Mice Fed a High-Fat Diet.”
2023-08-28 21:48:19
Authors: William Blaner
Journal: Journal of Nutrition
“Enhancing diversity, equity, inclusion, and accessibility in eosinophilic gastrointestinal disease research: the consortium for eosinophilic gastrointestinal disease researchers’ journey.”
2023-08-14 21:43:19
Authors: Dominique Bailey
Journal: Therapeutic Advances in Rare Diseases
“Modeling Notch Activity and Lineage Decisions Using Intestinal Organoids.”
2023-06-14 22:00:30
Authors: Chia-Wei Cheng
Journal: Methods in Molecular Biology
“Modeling Notch Activity and Lineage Decisions Using Intestinal Organoids.”
2023-06-14 21:56:37
Authors: Chia-Wei Cheng
Journal: Methods in Molecular Biology
“Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism.”
2023-03-28 21:39:48
Authors: Anne-Catrin Uhlemann, Nicholas Arpaia
Journal: Cell Reports
“The gut microbiome, short chain fatty acids, and related metabolites in cystic fibrosis patients with and without colonic adenomas.”
2023-01-23 21:14:12
Authors: Anne-Catrin Uhlemann, Julian Abrams
Journal: Journal of Cystic Fribrosis
“Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.”
2022-10-05 20:56:00
Authors: Nicholas Arpaia, Utpal Pajvani, Helen Remotti, Ira Tabas, Robert Schwabe
Journal: Nature
TTC39B destabilizes retinoblastoma protein promoting hepatic lipogenesis in a sex-specific fashion.
2022-02-26 17:50:13
Authors: Hsieh J, Molusky MM
Journal: J Hepatol
Loss of the wild-type KRAS allele promotes pancreatic cancer progression through functional activation of YAP1.
2022-02-26 17:35:44
Authors: Yan H, Yu CC
Journal: Oncogene
TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis.
2022-02-26 17:23:30
Authors: Wang X, Zeldin S
Journal: J Hepatol
Addressing dyslipidemic risk beyond LDL-cholesterol.
2022-02-26 17:19:08
Authors: Tall AR, Thomas DG
Journal: J Clin Invest
Are There Bad ICU Rooms? Temporal Relationship between Patient and ICU Room Microbiome, and Influence on Vancomycin-Resistant EnterococcusColonization.
2022-02-26 17:12:02
Authors: Freedberg DE, Richardson M
Journal: mSphere
Estimated Cost-effectiveness of Medical Therapy, Sleeve Gastrectomy, and Gastric Bypass in Patients With Severe Obesity and Type 2 Diabetes.
2022-02-26 16:50:34
Authors: Lauren BN, Lim F, Krikhely A
Journal: JAMA Netw Open
Multiplexed single-cell analysis reveals prognostic and non-prognostic T cell types in human colorectal cancer.
2022-02-26 15:53:27
Authors: Masuda K, Kornberg A
Journal: JCI Insight
A Microsatellite in the Coding Sequence of HLA-A/B Is a Mutation Hotspot in Colon Cancer With Microsatellite Instability.
2022-02-26 15:42:01
Authors: Raab WJ, Mazzocchi A, Radice P, Sahoo D, Castelli C, Dalerba P
Journal: Gastroenterology
The gut, its microbiome, and the brain: connections and communications
2021-09-23 18:19:18
Authors: Michael D Gershon, Kara Gross Margolis
Journal: J Clin Invest
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
2021-05-01 00:00:00
Authors: Utpal Pajvani Lab
Journal: Nat Commun
Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York
2021-05-01 00:00:00
Authors: Catrin Uhlemann Lab
Journal: Nature
Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome
2021-05-01 00:00:00
Authors: Fay Kastrinos and Chir Hur Labs
Journal: Gastroenterology
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
2021-05-01 00:00:00
Authors: Utpal Pajvani and Ira Tabas Labs
Journal: Sci Transl Med
Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression
2021-05-01 00:00:00
Authors: Timothy Wang and Ken Olive Labs
Journal: Gut
Maladaptive regeneration – the reawakening of developmental pathways in NASH and fibrosis
2021-05-01 00:00:00
Authors: Utpal Pajvani, Ira Tabas, and Robert Schwabe Groups
Journal: Nat Rev Gastroenterol Hepatol
Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice
2021-05-01 00:00:00
Authors: Timothy Wang
Journal: Gut
Mutant p53 regulates Survivin to foster lung metastasis
2021-05-01 00:00:00
Authors: Anil Rustgi, Jianhuan Hu, and dHiroshi Nakagawa Labs
Journal: Genes Dev
Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features
2021-05-01 00:00:00
Authors: Utpal Pajvani and Robert Schwabe Labs
Journal: J Hepatol
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice
2021-05-01 00:00:00
Authors: Timothy Wang and Helen Remotti Labs
Journal: Gastroenterology
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
2021-05-01 00:00:00
Authors: Robert Schwabe, Nicholas Arpaia, Helen Remotti, and Peter Sims Labs
Journal: Cancer Cell
PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
2021-05-01 00:00:00
Authors: Anil Rustgi Lab
Journal: Cancer Discov
Robust direct digital-to-biological data storage in living cells
2021-05-01 00:00:00
Authors: Harris Wang Lab
Journal: Nat Chem Biol
Stem cells and origins of cancer in the upper gastrointestinal tract
2021-05-01 00:00:00
Authors: Hiroshi Nakagawa, Anil Rustgi, Jianwen Que, and Timothy Wang
Journal: Cell Stem Cell
Systematic dissection of σ70 sequence diversity and function in bacteria
2021-05-01 00:00:00
Authors: Harris Wang Lab
Journal: Cell Rep
The Microbiota-Gut-Brain Axis: From Motility to Mood
2021-05-01 00:00:00
Authors: Kara Margolis
Journal: Gastroenterology
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts
2021-05-01 00:00:00
Authors: Robert Schwabe, Nicholas Arpaia, Peter Sims, and Ken Olive Labs
Journal: J Clin Invest
Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single-Center Report
2020-05-01 00:00:00
Authors: Mercedes Martinez and Kara Margolis Groups
Journal: Hepatology
Acute Liver Injury in COVID-19: Prevalence and Association with Clinical Outcomes in a Large U.S. Cohort
2020-05-01 00:00:00
Authors: Elizabeth Verna
Journal: Hepatology
BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract
2020-05-01 00:00:00
Authors: Jianwen Que
Journal: Annu Rev Physiol
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
2020-05-01 00:00:00
Authors: Ira Tabas, Utpal Pajvani, and Robert Schwabe Groups
Journal: Cell Metabol
Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation
2020-05-01 00:00:00
Authors: Elizabeth Verna's Group
Journal: Hepatology
Cysteine depletion induces pancreatic tumor ferroptosis in mice
2020-05-01 00:00:00
Authors: Kenneth Olive's Group
Journal: Science
DAA therapy and long-term hepatic function in advanced/decompensated cirrhosis: Real-world experience from HCV-TARGET cohort
2020-05-01 00:00:00
Authors: Elizabeth Verna's Group
Journal: J Hepatol
Efferocytosis in health and disease
2020-05-01 00:00:00
Authors: Ira Tabas
Journal: Nat Rev Immunol
Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study
2020-05-01 00:00:00
Authors: Daniel Freedberg, Julian Abrams, and Timothy Wang
Journal: Gastroenterology
Gastrointestinal Symptoms and Coronavirus Disease 2019: A Case-Control Study From the United States
2020-05-01 00:00:00
Authors: Daniel Freedberg, Benjamin Lebwohl, and Timothy Wang Groups
Journal: Gastroenterology
Gastrointestinal Symptoms as a Major Presentation Component of a Novel Multisystem Inflammatory Syndrome in Children That Is Related to Coronavirus Disease 2019: A Single Center Experience of 44 Cases
2020-05-01 00:00:00
Authors: Mercedes Martinez and Kara Margolis Groups
Journal: Gastroenterology
Gut microbiome in HCC – Mechanisms, diagnosis and therapy
2020-05-01 00:00:00
Authors: Robert Schwabe
Journal: J Hepatol
Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response
2020-05-01 00:00:00
Authors: Ken Olive, Yang Han, and Helen Remotti Groups
Journal: Clin Cancer Res
Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis
2020-05-01 00:00:00
Authors: Timothy Wang's Group
Journal: Cell Stem Cell
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
2020-05-01 00:00:00
Authors: Ira Tabas, Bill Blaner, and Robert Schwabe Groups
Journal: Cell Metabol
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
2020-05-01 00:00:00
Authors: Robert Schwabe, Ira Tabas, and Utpal Pajvani Groups
Journal: Gastroenterology
Mechanobiology of vertebrate gut morphogenesis
2020-05-01 00:00:00
Authors: Nandan Nerurkar
Journal: Curr Opin Genet Dev
Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
2020-05-01 00:00:00
Authors: Timothy Wang and Kelley Yan Groups
Journal: Nat Commun
Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform
2020-05-01 00:00:00
Authors: Harris Wang and Daniel Freedberg Groups
Journal: Nat Commun
SnapShot: Ferroptosis
2020-05-01 00:00:00
Authors: Brent Stockwell
Journal: Cell