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The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
We love digestive research. We enjoy working in teams. We embrace diversity. Together we will achieve more.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center

Pilot and Feasibility Program

The Pilot and Feasibility Program (P/F) oversees pilot and feasibility award review and funding. These grants seek to stimulate innovative ideas and interactive projects, with a focus on priming the careers of junior investigators; and bringing transformative science into the field of digestive disease research. The program will solicit applications from new investigators seeking initial support or established researchers aiming to pursue high-risk, high-reward projects that are a clear departure from their ongoing interests, as well as investigators from other fields trying to apply their expertise into research in gastroenterology or hepatology. The P/F program seeks to promote DEI, and encourages applications from reseachers identified as underrepresented in the biomedical sciences, including individuals from underrepresented racial and ethnic groups; individuals with disabilities; and individuals from disadvantaged backgrouns.  In addition to research funds, P/F awardees will also receive discounted CU-DLDRC core services for three years.

The next round of P/F grants will be funded in July 2022 (letter of intent due 3/15/2022; full applications due 5/1/2022), further details will be announced through this website and via email in early 2022.

  • Congratulations to P/F awardee Nandan Nerurkar for his recently awarded grant R35GM142995 “Investigation of a neuromesendodermal progenitor population in the posterior avian endoderm“.
  • Congratulations to P/F awardee  Nicholas Arpaia for his recently awarded grant R01CA259634 “Treating colon cancer by regulating intestinal immunity through microbial metabolism“.
  • Congratulations to P/F awardee Ji-Yeon Shin for her recently awarded AASLD Pinnacle Award “LAP1-torsinA complex in NASH and HCC development“.

The Pilot & Feasibility Program has funded seven researchers with a total of $175,000 from 2019 to 2021.

Pilot & Feasibility-funded researchers have obtained a total of $5,592,000 funding to date.

Leadership

Kara Gross-Margolis, MD
Associate Professor, Pediatric Gastroenterology, Hepatology and Nutrition
Director, Pediatrician Scientist Training and Development Program
Department of Pediatrics
Columbia University
Website
Utpal Pajvani, MD, PhD
Herbert Irving Associate Professor of Medicine
Department of Medicine
Columbia University
Website | Profile

2021 Pilot and Feasibility Grant Awardees

Eunhee Choi, PhD
for her project: "Spatiotemporal Regulation of Insulin Signaling in the Liver
Joel Gabre, MD
for his project: “The Role of EPHA2 in SOX2 Mediated Signaling During Esophageal Development

2020 Pilot and Feasibility Grant Awardees

Ji-Yeon Shin, PhD
for her project: “LAP1-torsin A complex in NASH and HCC development
Mijo Simunovic, PhD
for his project: “A quantitative platform to study the gut-microbiomeimmune system interface in human development and disease

2019 Pilot and Feasibility Grant Awardees

Nicholas Arpaia, PhD
for his project: “Interrogating the relationship between microbial metabolism and mucosal immunity
Daniel Freedberg, MD, MS
for his project: “Preventing multidrug-resistant organism enteric colonization in the intensive care unit
Nandan Nerurkar, PhD
for his project: “Molecular and cellular basis of intestinal morphogenesis