Clinical Biospecimen and Research Core (CBRC)
The Clinical Biospecimen and Research Core (CBRC) will provide a large number of stored biospecimens from the gastrointestinal tract and liver as well as assistance with biospecimen processing for the effective translation of laboratory findings into the clinical setting. The core provides skilled support in sample management including procurement, processing and storage; histological and single nuclueus RNA-seq analysis and data management. Thereby, it will provide assistance in transferring laboratory research concepts into clinical trials and development with the goal of accelerating research and trials. A particular focus on CBRC will be to link its biospecimens to services provided by the other CU-DLDRC cores. The CBRC seeks to achieve this mission through four clinical basic teams (CBT), providing structures to catalyze day-to-day collaboration between clinical and basic researchers in a traditional organ-focused manner.
- Provide access to, via a searchable Laboratory Information Management System (Open Specimen), to an extensive biospecimen collection with linked clinical metadata
- On-demand procurement of fresh tissue from three CU-DLDRC focus areas (upper GI, intestine and liver; pancreas provided at a later state)
- Coordinate tissue processing and analyses, including RNA extraction, histopathologic services including tissue microarray construction, as well as subsidized single nucleus isolation and snRNA-sequencing of frozen clinical samples.
- Facilitate clinical research that advances the goals of CU-DLDRC members via tailored consultative services and educational resources for study design and execution, database development and statistical support.
- Four organ-focused clinical-basic teams (CBTs – liver, upper GI, intestine; pancreas in the future) that will meet bimonthly and realize the fruitful exchange and collaboration between clinical and basic researchers .
CBRC is already working with CU-DLDRC researchers to provide select samples and services. Please contact core directors Julian Abrams and Elizabeth Verna for specific project needs.