&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
We love digestive research. We enjoy working in teams. We embrace diversity. Together we will achieve more.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center
&nbsp
 
The Columbia University Digestive and Liver Diseases Research Center (CU-DLDRC) promotes collaborative and multidisciplinary research in digestive and liver diseases, integrating expertise in clinical and basic gastroenterology and hepatology with state-of-the-art computational bioinformatics.

We support collaboration among different specialties and backgrounds and promote innovative and creative research approaches. We unite investigators with interests in digestive, liver, and pancreatic physiology and disease in the exploration of creative experimental approaches.
Columbia University
Digestive and Liver Diseases Research Center

Clinical Biospecimen and Research Core (CBRC)

The Clinical Biospecimen and Research Core (CBRC) will provide a large number of stored biospecimens from the gastrointestinal tract and liver as well as assistance with biospecimen processing for the effective translation of laboratory findings into the clinical setting. The core provides skilled support in sample management including procurement, processing and storage; histological and single nuclueus RNA-seq analysis and data management. Thereby, it will provide assistance in transferring laboratory research concepts into clinical trials and development with the goal of accelerating research and trials. A particular focus on CBRC will be to link its biospecimens to services provided by the other CU-DLDRC cores. The CBRC seeks to achieve this mission through four clinical basic teams (CBT), providing structures to catalyze day-to-day collaboration between clinical and basic researchers in a traditional organ-focused manner.

  • Provide access to, via a searchable Laboratory Information Management System (Open Specimen), to an extensive biospecimen collection with linked clinical metadata
  • On-demand procurement of fresh tissue from three CU-DLDRC focus areas (upper GI, intestine and liver; pancreas provided at a later state)
  • Coordinate tissue processing and analyses, including RNA extraction, histopathologic services including tissue microarray construction, as well as subsidized single nucleus isolation and snRNA-sequencing of frozen clinical samples.
  • Facilitate clinical research that advances the goals of CU-DLDRC members via tailored consultative services and educational resources for study design and execution, database development and statistical support.
  • Four organ-focused clinical-basic teams (CBTs – liver, upper GI, intestine; pancreas in the future) that will meet bimonthly and realize the fruitful exchange and collaboration between clinical and basic researchers .

We anticipate CBRC to be in operation in April 2022. An update will be provided on the website in December 2021 and a seminar in spring 2022. Once the core starts, a detailed list of services and fee schedule will be provided through this website and the iLab system.

CBRC is already working with CU-DLDRC researchers to provide select samples and services. Please contact core directors Julian Abrams and Elizabeth Verna for specific project needs.

Leadership

Julian Abrams, MD
Associate Professor
Department of Medicine
Columbia University
Profile
Elizabeth Verna, MD
Associate Professor
Department of Medicine
Columbia University
Profile