The Bioimaging Core (BIC) provides state-of-the-art and functional imaging techniques to precisely study mechanisms of health and disease of the digestive tract and liver. Besides a sophisticated suite of confocal, multiphoton, super-resolution and total internal reflection fluorescence microscopes, the small animal imaging unit will provide magnetic resonance imaging, ultrasound imaging, computed tomography imaging, and optical imaging of mice to functionally study signaling and metabolic pathways. These analyses are complemented by the development of high resolution MALDI imaging to detect virtually any small molecule at a near single cell level as well as SCAPE imaging, a novel near microscopy-resolution optical platform based on endogenous tissue fluorescence in small animals and tissues. Multi-core workflows will integrate analyses with the other CU-DLDRC cores.
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The Clinical Biospecimen and Research Core (CBRC) will provide a repository of stored biospecimens from the gastrointestinal tract and liver. The core provides skilled support in sample management including procurement, processing and storage; histological and single nucleus RNA-seq of human biospecimens; as well as data management. The overall goal is to provide assistance in transferring laboratory research concepts into clinical trials and development with the goal of accelerating research and trials so that it can make an impact in the clinic as early as reasonably possible. A particular focus on CBRC will be to link its biospecimens to services provided by the other CU-DLDRC cores. The CBRC seeks to achieve its mission of link clinical biospecimens and data to novel research concepts through four organ-focused clinical basic teams (CBT) that will connect clinical and basic researchers and fertilize translational research.