Organoid & Cell Culture Core (OCCC)
The Organoid and Cell Culture Core (OCCC) generates models that replicate the structural and functional complexity of the gastrointestinal tract and liver. The core offers a wide range of cryopreserved mouse and human organoids from various sites of the digestive tract (esophagus, stomach intestine, pancreas, liver), including organoids from transgenic mice, e.g. expressing Cas9 and dCas9. The core also offers a repository of passage-annotated and myoplasma-free cell cell lines, as well as advanced 3D cell culture platforms, protocols and technologies. Through collaborations with other CU-DLDRC cores, OCCC will assist CU-DLDRC members to functionally analyze transcriptional regulators, e.g. through Cas9 and dCas9-transgenic organoids and organoid- and cell-based drug and CRISPR screens. Make a Service Request